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Abstract/Syllabus:
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Yannas, Ioannis, and Myron Spector, 20.441J Biomaterials-Tissue Interactions, Fall 2009. (Massachusetts Institute of Technology: MIT OpenCourseWare), http://ocw.mit.edu (Accessed 09 Jul, 2010). License: Creative Commons BY-NC-SA
Biomaterials-Tissue Interactions (BE.441)
Fall 2003
The hip prosthesis is a widely used and successful example of a permanent medical implant. (Image courtesy of OCW.)
Course Highlights
This course features extensive lecture notes as well as a complete set of homework assignments.
Course Description
This course is an introduction to principles of materials science and cell biology underlying the design of medical implants, artificial organs, and matrices for tissue engineering. Topics include methods for biomaterials surface characterization and analysis of protein adsorption on biomaterials. Molecular and cellular interactions with biomaterials are analyzed in terms of unit cell processes, such as matrix synthesis, degradation, and contraction. It also covers mechanisms underlying wound healing and tissue remodeling following implantation in various organs. Other areas include tissue and organ regeneration; design of implants and prostheses based on control of biomaterials-tissue interactions; comparative analysis of intact, biodegradable, and bioreplaceable implants by reference to case studies. Also addressed are criteria for restoration of physiological function for tissues and organs.
Syllabus
Course Description
This course is an introduction to principles of materials science and cell biology underlying the design of medical implants, artificial organs, and matrices for tissue engineering. Topics include methods for biomaterials surface characterization and analysis of protein adsorption on biomaterials. Molecular and cellular interactions with biomaterials are analyzed in terms of unit cell processes, such as matrix synthesis, degradation, and contraction. It also covers mechanisms underlying wound healing and tissue remodeling following implantation in various organs. Other areas include tissue and organ regeneration; design of implants and prostheses based on control of biomaterials-tissue interactions; comparative analysis of intact, biodegradable, and bioreplaceable implants by reference to case studies. Also addressed are criteria for restoration of physiological function for tissues and organs.
Text
Yannas, I. V. Tissue and Organ Regeneration in Adults. New York, NY: Springer, 2001. ISBN: 9780387952147.
Prerequisites
3.091 or 5.11 or 5.111 or 5.112
2.005 or 5.60
7.012 or 7.013
Calendar
The calendar below provides information on the course's lecture (L) and exam (E) sessions.
| SES # |
TOPICS |
KEY DATES |
| I. Tissue Environment of the Implanted Biomaterial: Unit Cell Processes |
| L1 |
Survey of Clinical Cases of Biomaterials-Tissue Interactions |
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| L2 |
Tissue Structures, Unit Cell Processes, and Integrins |
Homework 1 due |
| L3 |
Unit Cell Processes Comprising the Healing Response |
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| L4 |
Irreversible Healing Behavior of the Extracellular Matrix (ECM) of Organs |
Homework 2 due |
| L5 |
Biochemistry of the ECM |
Homework 3 due |
| L6 |
Scaffolds Based on ECM Analogs Used in Organ Synthesis |
|
| L7 |
Organ Replacement by Induced Regeneration and Tissue Engineering |
|
| L8 |
Principles and Practice of Tissue Engineering |
Homework 4 due |
| E1 |
Quiz 1 |
|
| II. Physicochemical Interactions at the Surface of Biomaterials and Signaling within Tissue |
| L9 |
Characteristics of the Surfaces of Biomaterials |
|
| L10 |
Methodology for the Analysis of Surfaces |
|
| L11 |
Physicochemical Principles of Protein Adsorption on Solid Surfaces |
Homework 5 due |
| L12 |
Protein/Cell/Tissue-Biomaterials Interactions |
Homework 6 due |
| L13 |
Linear vs. Cooperative Cell-Matrix Interactions |
Homework 7 due |
| L14 |
Cell-Matrix Interactions During Spontaneous Healing |
|
| L15 |
Contraction-Blocking Theory of Regeneration in Adults |
|
| E2 |
Quiz 2 |
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| III. In Vivo and Clinical Case Studies |
| L16 |
Joints and Dental Tissues: Prosthetic Replacement |
|
| L17 |
Joints and Dental Tissues: Regeneration 1 |
|
| L18 |
Joints and Dental Tissues: Regeneration 2 |
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| L19 |
Epithelialization (Epidermal Regeneration) and Endothelialization of Vascular Prostheses |
|
| L20 |
Rules for Synthesis of Tissues and Organs |
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| L21 |
In Vivo Synthesis of Skin |
Homework 8 due |
| L22 |
In Vivo Synthesis of Peripheral Nerves |
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| L23 |
In Vivo Synthesis of the Conjunctiva and of Kidney Tissue |
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| E3 |
Quiz 3 |
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Further Reading:
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Readings
Text
Yannas, I. V. Tissue and Organ Regeneration in Adults. New York, NY: Springer, 2001. ISBN: 9780387952147.
| SES # |
TOPICS |
TEXT READINGS |
ADDITIONAL REFERENCES |
| I. Tissue Environment of the Implanted Biomaterial: Unit Cell Processes |
| L1 |
Survey of Clinical Cases of Biomaterials-Tissue Interactions |
|
Survey of Clinical Cases of Biomaterials-Tissue Interactions: The Paradigm (PDF) |
| L2 |
Tissue Structures, Unit Cell Processes, and Integrins |
|
Giancotti, F. G., and E. Ruoslahti. "Integrin Signaling." Science 285 (13 Aug 1999): 1028-1032.
This paper presents the concept of integrin signaling.
Ruoslathi, E., and M. D. Pierschbacher. "New Perspectives in Cell Adhesion: RGD and Integrins." Science 238, no. 4826 (23 Oct 1987): 491-497.
This paper describes the discovery of an amino acid sequence that is a ligand for integrins.
Working/Operational Definitions (PDF)
Tissue Structure/Unit Cell Processes (PDF) |
| L3 |
Unit Cell Processes Comprising the Healing Response |
|
|
| L4 |
Irreversible Healing Behavior of the Extracellular Matrix (ECM) of Organs |
Chapters 1-4 |
|
| L5 |
Biochemistry of the ECM |
|
Extracellular Matrix Molecules (PDF) |
| L6 |
Scaffolds Based on ECM Analogs Used in Organ Synthesis |
Chapter 8 |
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| L7 |
Organ Replacement by Induced Regeneration and Tissue Engineering |
|
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| L8 |
Principles and Practice of Tissue Engineering |
|
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| E1 |
Quiz 1 |
|
|
| II. Physicochemical Interactions at the Surface of Biomaterials and Signaling within Tissue |
| L9 |
Characteristics of the Surfaces of Biomaterials |
|
Characteristics of the Surfaces of Biomaterials (PDF) |
| L10 |
Methodology for the Analysis of Surfaces |
|
Ratner, B. D. "Surface Properties of Biomaterials." In Biomaterials Science. Edited by B. D. Ratner, et. al. Burlington, MA: Academic Press, 1996. ISBN: 9780125824606.
Methodology for Chemical Analysis of Surfaces (PDF) |
| L11 |
Physicochemical Principles of Protein Adsorption on Solid Surfaces |
|
Andrade, J. D. "Principles of Protein Adsorption." In Surface and Interfacial Aspects of Biomedical Polymers. Vol. 2. Edited by J. D. Andrade. NY: Plenum Press, 1985.
Chinn, J. A., et. al. "Postadsorptive transitions in fibrinogen adsorbed to polyurethanes." Journal of Biomedical Materials Research 26 (1992): 757-778.
Rapoza, R. J., and T. A. Horbett. "Postadsorptive transitions in fibrinogen: Influence of polymer properties." Journal of Biomedical Materials Research 24 (1990): 1263-1287. |
| L12 |
Protein/Cell/Tissue-Biomaterials Interactions |
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| L13 |
Linear vs. Cooperative Cell-Matrix Interactions |
|
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| L14 |
Cell-Matrix Interactions During Spontaneous Healing |
Chapter 9 |
|
| L15 |
Contraction-Blocking Theory of Regeneration in Adults |
Chapters 8 and 10 |
|
| E2 |
Quiz 2 |
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| III. In Vivo and Clinical Case Studies |
| L16 |
Joints and Dental Tissues: Prosthetic Replacement |
|
Joints: Regeneration of Bone, Cartilage, Meniscus, Ligament, and Tendon (PDF) |
| L17 |
Joints and Dental Tissues: Regeneration 1 |
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| L18 |
Joints and Dental Tissues: Regeneration 2 |
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| L19 |
Epithelialization (Epidermal Regeneration) and Endothelialization of Vascular Prostheses |
|
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| L20 |
Rules for Synthesis of Tissues and Organs |
Chapter 7 |
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| L21 |
In Vivo Synthesis of Skin |
Chapter 5 |
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| L22 |
In Vivo Synthesis of Peripheral Nerves |
Chapter 6 |
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| L23 |
In Vivo Synthesis of the Conjunctiva and of Kidney Tissue |
Chapter 8 |
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| E3 |
Quiz 3 |
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