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Abstract/Syllabus:
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Molecular and Cellular Pathophysiology (BE.450)
Spring 2005
A comparison of the Hepatitis B, C, and D viruses. (Figure by MIT OCW.)
Course Highlights
This course features a comprehensive set of lecture notes and examples of student work on the course assignments.
Course Description
This course focuses on the fundamentals of tissue and organ response to injury from a molecular and cellular perspective. There is a special emphasis on disease states that bridge infection, inflammation, immunity, and cancer. The systems approach to pathophysiology includes lectures, critical evaluation of recent scientific papers, and student projects and presentations.
This term, we focus on hepatocellular carcinoma (HCC), chronic-active hepatitis, and hepatitis virus infections. In addition to lectures, students work in teams to critically evaluate and present primary scientific papers.
Syllabus
This course grants graduate level credit.
Prerequisite
20.420J and 20.440, or permission of instructor.
Course Description
This course focuses on the fundamentals of tissue and organ response to injury from a molecular and cellular perspective. There is a special emphasis on disease states that bridge infection, inflammation, immunity, and cancer. The systems approach to pathophysiology includes lectures, critical evaluation of recent scientific papers, and student projects and presentations.
This term, we focus on hepatocellular carcinoma (HCC), chronic-active hepatitis, and hepatitis virus infections. In addition to lectures, students work in teams to critically evaluate and present primary scientific papers.
Text
Readings are in the form of primary scientific papers, reviews, and selected chapters from the following text:
Kumar, Vinay, Abul K. Abbas, and Nelson Fausto, eds. Robbins and Cotran Pathologic Basis of Disease. 7th ed. Philadelphia, PA: Elsevier Saunders, 2004. ISBN: 9780721601878.
Grading
| ACTIVITIES |
PERCENTAGES |
| Participation |
25% |
| Midterm Exam |
25% |
| Presentations |
25% |
| Final Exam |
25% |
Calendar
Key:
DS = Prof. David Schauer
AR = Dr. Arlin Rogers (Guest lecturer, MIT Division of Comparative Medicine)
Calendar table.
| LEC # |
TOPICS |
INSTRUCTORS |
KEY DATES |
| 1 |
Introduction to 20.450 and HCC |
DS |
|
| 2-3 |
Cellular Pathology |
DS |
|
| 4-5 |
Inflammation |
DS |
Student presentation 1 due |
| 6 |
Liver Anatomy and Histology |
AR |
|
| 7-9 |
Immunity |
DS |
Student presentation 2 due |
| 10 |
Neoplasia |
DS |
Student presentation 3 due |
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Midterm Exam |
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| 11 |
Neoplasia (cont.) |
DS |
|
| 12-13 |
Infectious Diseases |
DS |
|
| 14 |
Liver and Biliary |
DS |
|
| 15-16 |
Hepatocarcinogenesis |
DS |
Student presentation 4 due |
| 17-18 |
Animal Models |
AR |
|
| 19-22 |
Special Topic |
DS |
Student presentation 5 due |
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Final Exam |
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Further Reading:
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Readings
Required Readings
Many of the readings for this course come from the following text:
Kumar, Vinay, Abul K. Abbas, and Nelson Fausto, eds. Robbins and Cotran Pathologic Basis of Disease. 7th ed. Philadelphia, PA: Elsevier Saunders, 2004. ISBN: 9780721601878.
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Course readings.
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LEC #
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TOPICS
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READINGS
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1
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Introduction to 20.450 and HCC
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Sherlock, G. "Analysis of large-scale gene expression data." Current Opinion in Immunology 12, no. 2 (April 2000): 201-5. Review.
HBV slideset from the CDC
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2-3
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Cellular Pathology
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"Cellular Adaptations, Cell Injury, and Cell Death." Chapter 1 in Robbins and Cotran. pp. 3-46.
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4-5
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Inflammation
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"Acute and Chronic Inflammation." Chapter 2 in Robbins and Cotran. pp. 47-86.
Coussens, L. M., and Z. Werb. "Inflammation and cancer." Nature 420, no. 6917 (December 19-26, 2002): 860-7. Review.
Muller, A., et al. "Involvement of chemokine receptors in breast cancer metastasis." Nature 410, no. 6824 (March 1, 2001): 50-6.
Liotta, L. A. "An attractive force in metastasis." Nature 410, no. 6824 (March 1, 2001): 24-5.
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6
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Liver Anatomy and Histology
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"Liver and Biliary Tract." Chapter 18 in Robbins and Cotran. pp. 878-879.
"Tissue Renewal and Repair: Regeneration, Healing, and Fibrosis." Chapter 3 in Robbins and Cotran. pp. 87-118.
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7-9
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Immunity
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"Diseases of Immunity." Chapter 6 in Robbins and Cotran. pp. 193-240.
Prasad, S. J., et al. "Dendritic cells loaded with stressed tumor cells elicit long-lasting protective tumor immunity in mice depleted of CD4+CD25+ regulatory T cells." Journal of Immunology 174, no. 1 (January 1, 2005): 90-8.
Rehermann, B., and M. Nascimbeni. "Immunology of hepatitis B virus and hepatitis C virus infection." Nature Review Immunology 5, no. 3 (March 2005): 215-29.
Crispe, I. N. "Hepatic T cells and liver tolerance." Nature Review Immunology 3, no. 1 (January 2003): 51-62.
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10
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Neoplasia
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"Neoplasia." Chapter 7 in Robbins and Cotran. pp. 269-339.
Li, et al. "Accurate qualitative and quantitative proteomic analysis of clinical hepatocellular carcinoma using laser capture microdissection coupled with isotope-coded affinity tag and two-dimensional liquid chromatography mass spectrometry." Molecular and Cellular Proteomics 3, no. 4 (April 2004): 399-409.
Ding, S. J., et al. "From proteomic analysis to clinical significance: overexpression of cytokeratin 19 correlates with hepatocellular carcinoma metastasis." Molecular and Cellular Proteomics 3, no. 1 (January 2004): 73-81.
Staib, F., S. P. Hussain, L. J. Hofseth, X. W. Wang, and C. C. Harris. "TP53 and liver carcinogenesis." Human Mutation 21, no. 3 (March 2003): 201-16. Review.
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Midterm Exam
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11
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Neoplasia (cont.)
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See readings for above Neoplasia lecture
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12-13
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Infectious Diseases
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"Infectious Diseases." Chapter 8 in Robbins and Cotran. pp. 343-411.
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14
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Liver and Biliary
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"Liver and Biliary Tract." Chapter 18 in Robbins and Cotran. pp. 877-936.
Carey, M. C., R. S. Kwon, K. J. Maurer, and J. G. Fox. "State of the art - gallstone research in the post-genomic era." Falk Symposium 139 (2004): 207-25.
Rogers, A. B., and J. G. Fox. "Inflammation and Cancer. I. Rodent models of infectious gastrointestinal and liver cancer." American Journal of Physiology - Gastrointestinal and Liver Physiology 286, no. 3 (March 2004): G361-6. Review.
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15-16
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Hepatocarcinogenesis
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Iizuka, N., et al. "Self-organizing-map-based molecular signature representing the development of hepatocellular carcinoma." FEBS Letters 579, no. 5 (February 14, 2005): 1089-100.
Wielockx, B., K. Lannoy, S. D. Shapiro, T. Itoh, S. Itohara, J. Vandekerckhove, and C. Libert. "Inhibition of matrix metalloproteinases blocks lethal hepatitis and apoptosis induced by tumor necrosis factor and allows safe antitumor therapy." Nature Medicine 7, no. 11 (November 2001): 1202-8.
Benyon, R. C., and M. J. Arthur. "Extracellular matrix degradation and the role of hepatic stellate cells." Seminars in Liver Disease 21, no. 3 (August 2001): 373-84.
Kensler, T. W., P. A. Egner, J. B. Wang, Y. R. Zhu, B. C. Zhang, P. X. Lu, J. G. Chen, G. S. Qian, S. Y. Kuang, P. E. Jackson, S. J. Gange, L. P. Jacobson, A. Munoz, and J. D. Groopman. "Chemoprevention of hepatocellular carcinoma in aflatoxin endemic areas." Gastroenterology 127, no. 5 Suppl. 1 (November 2004): S310-8.
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17-18
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Animal Models
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19-22
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Special Topic
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Final Exam
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