Required Texts
Salsburg, D. The Lady Tasting Tea: How Statistics Revolutionized Science in the Twentieth Century. New York, NY: W. H. Freeman and Company, 2001. ISBN: 0716741067.
Gordis, L. Epidemiology. 3rd ed. Philadelphia, PA: Elsevier, 2004. ISBN: 0721603262.
Schork, M. A., and R. D. Remington. Statistics with Applications to the Biological and Health Sciences. 3rd ed. Upper Saddle River, NJ: Prentice-Hall, 2000. ISBN: 0130223271.
Grading Policy
Percentage contributions to the final grade are as follows:
Grading Table
Activities |
Percentages |
Quizzes (Two, 25% each)
|
50%
|
Homework Assignments (10-page Book Critique, 10%; 5 Problem Sets, 15%)
|
25%
|
Team Project (Team Project Paper, 15%; Team Project Presentation, 10%)
|
25%
|
Recitations
There will be optional weekly recitation sessions offered throughout the term. However, students are strongly encouraged to attend. In addition to answering questions relating to the lecture material, homework assignments, and projects, the TA will provide background help with concepts in several areas, including epidemiology and biostatistics for the first half and elements of chemistry and biochemistry and risk analyses for the second.
Reading Assignment for "The Lady Tasting Tea"
During the first half of the term, students are required to read The Lady Tasting Tea: How Statistics Revolutionized Science in the Twentieth Century, by David Salsburg. This book provides a historical introduction to statistical and environetics principles that will be the focus of the first half of the course. Students are expected to read the entire book. The purpose of this reading is to introduce students to the field of statistics and to prepare them for the concepts and language of uncertainty, which permeates statistical thought.
Problem Sets
Problem sets are due as noted in the lecture schedule. There will be a 20% reduction in the grade for each day that a problem set is late.
Quizzes
There will be two quizzes during the term. The second quiz will only cover material presented after the first quiz. Quizzes will be given in-class during the regular lecture period as noted in the schedule. Quiz #1 is open book. The format of Quiz #2 will be determined by instructors. There is no final examination.
Team Project
Students will be grouped into teams of 3-4 students to work jointly on a project to investigate an environmental agent for which there is reason for concern about possible adverse health effects for human populations. The investigation will center on concepts developed during the term, with emphasis on relating environmental exposures and toxicological mechanisms to quantitative risk assessment of potential health effects.
Calendar
Course schedule.
Lec # |
Topics |
INSTRUCTORS |
KEY DATES |
1
|
Introductory Lecture
|
Prof. James Sherley
Prof. Steven Tannenbaum
Dr. Laura Green
|
|
2
|
Watch film A Civil Action
|
Prof. James Sherley
Prof. Steven Tannenbaum
Dr. Laura Green
|
|
3
|
From the Real World to Hollywood and Back Again
|
Dr. Laura Green
|
|
4
|
Epidemiology: Persons, Places, and Time
|
Prof. James Sherley
|
|
5
|
Epidemiology: Test Development and Relative Risk
|
Prof. James Sherley
|
|
6
|
Biostatistics: Concepts in Variance
|
Prof. James Sherley
|
Problem set 1 Epidemiology out
|
7
|
Biostatistics: Distribution and the Mean
Confidence Intervals
|
Prof. James Sherley
|
Problem set 2 Biostatistics 1 out
Problem set 1 Epidemiology due
|
8
|
Biostatistics: Detecting Differences and Correlations
|
Prof. James Sherley
|
|
9
|
Biostatistics: Poisson Analyses and Power
|
Prof. James Sherley
|
Problem set 3 Biostatistics 2 out
Problem set 2 Biostatistics 1 due
Team project topic deadline
|
10
|
Environetics: Cause and Effect
|
Prof. James Sherley
|
|
11
|
Environetics: Study Design - Retrospective versus Prospective
|
Prof. James Sherley
|
Problem set 3 Biostatistics 2 due
Team project approvals completed
|
12
|
Environetics: Putting it all together - Evaluating Studies
|
Prof. James Sherley
|
Lady Tasting Tea
10-page review due |
13
|
Quiz #1: Epidemiology-Biostatistics
|
Prof. James Sherley
|
|
14
|
Evaluating Environmental Causes of Mesothelioma
|
Prof. James Sherley
|
|
15
|
Quantitative Risk Assessment 1
|
Dr. Laura Green
|
|
16
|
Quantitative Risk Assessment 2
|
Dr. Laura Green
|
|
17
|
Toxicology 1
|
Prof. Steven Tannenbaum
|
|
18
|
Toxicology 2
|
Prof. Steven Tannenbaum
|
Problem set 4 Toxicology 1 out
|
19
|
Toxicology 3
|
Prof. Steven Tannenbaum
|
|
20
|
Toxicology 4
|
Prof. Steven Tannenbaum
|
Problem set 5 Toxicology 2 out
Problem set 4 Toxicology 1 due
|
21
|
Toxicology 5
|
Prof. Steven Tannenbaum
|
|
22
|
Quantitative Risk Assessment 3
|
Dr. Laura Green
|
Problem set 5 Toxicology 2 due
|
23
|
Quantitative Risk Assessment 4
|
Dr. Laura Green
|
|
24
|
Quiz #2: QRA-Toxicology
|
Dr. Laura Green
Prof. Steven Tannenbaum
|
|
25
|
Classroom Presentations of Team Projects
|
|
20-page team papers due in class
|
26
|
Classroom Presentations of Team Projects (cont.)
|
|