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Abstract/Syllabus:
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Epidemiology of Infectious Diseases
Fall 2006
Description
Introduces the basic methods for infectious disease epidemiology and case studies of important disease syndromes and entities. Methods include definitions and nomenclature, outbreak investigations, disease surveillance, case-control studies, cohort studies, laboratory diagnosis, molecular epidemiology, dynamics of transmission, and assessment of vaccine field effectiveness. Case-studies focus on acute respiratory infections, diarrheal diseases, hepatitis, HIV, tuberculosis, sexually transmitted diseases, malaria, and other vector-borne diseases.
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Syllabus
Course Description
Introduces the basic methods for infectious disease epidemiology and case studies of important disease syndromes and entities. Methods include definitions and nomenclature, outbreak investigations, disease surveillance, case-control studies, cohort studies, laboratory diagnosis, molecular epidemiology, dynamics of transmission, and assessment of vaccine field effectiveness. Case-studies focus on acute respiratory infections, diarrheal diseases, hepatitis, HIV, tuberculosis, sexually transmitted diseases, malaria, and other vector-borne diseases.
Course Objectives
- After taking the course in Infectious Diseases Epidemiology students will be able to describe and understand the main Epidemiological characteristics of the Major infectious diseases of Humans.
- The students will be able to describe how these Epidemiological characteristics can be utilized to develop and evaluate strategies to prevent epidemics or endemic transmission of the major infections of humans.
- The students will be able to develop criteria to be used in the investigation of a new Emerging or Re-emerging Infectious disease to understand the critical Epidemiologic features of this disease that could be used to develop prevention and control programs. Epidemiological characteristics such as Incubation period, Infectious period, means of transmission and reservoir of these infectious diseases will be evaluated
Prerequisites
Knowledge of basic epidemiology
Readings
Textbook: Kenrad E. Nelson & Carolyn Masters Williams. Infectious Disease Epidemiology: Theory and Practice. Second Edition. Jones and Bartlett Publishers, 2006. This text is designed to be used in the course; book chapters have been written by the course lecturers.
Readings: Supplemental course readings and journal articles are listed on the Readings page.
Course Requirements
Short paper: Each student must select one article from a list of articles relevant to the course topic and complete a peer review on that article. The peer review should be no longer than two pages.
Midterm: The midterm consists of short answer questions and will test students on Lectures 1-10.
Final: The final exam consists of multiple choice questions and will mainly test students on Lectures 11-20. Some questions related to Lectures 1-10 may also be addressed.
Overall Grading Structure
10% - Peer review paper and participation
30% - Midterm exam
60% - Final exam
Repurposing OCW Content
JHSPH OpenCourseWare encourages users to repurpose OCW content. If you have repurposed content from this course, please click here to let us know about it.
Schedule
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| 1 |
Introduction to Infectious Disease Epidemiology (Nelson) |
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| 2 |
Overview of Microbiology (Dick) |
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| 3 |
The Molecular Epidemiology of Infectious Disease (Bishai) |
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| 4 |
Modeling of Infectious Disease (Aron) |
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| 5 |
Case-Control Studies (Nelson) |
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| 6 |
Vaccines - Impact, Questions, and Challenges (Halsey) |
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| 7 |
Measles (Moss) |
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| 8 |
Disease Eradication (Nelson) |
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| 9 |
Beyond Osler: The Past, Present, and Future of Infection Control (Perl)
This lecture is not currently available
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| 10 |
Nutrition and Infection in the Developing World (West) |
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| 11 |
Epidemiology of Diarrheal Diseases (Black) |
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| 12 |
TB Epidemiology (Chaisson) |
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| 13 |
Influenza: Virus and Disease, Epidemics and Pandemics (Steinhoff) |
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| 14 |
CNS Viral Infections (Johnson) |
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| 15 |
Lyme Disease and Its Epidemiology (Griffin) |
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| 16 |
Meningococcal Disease: Global Problem, Local Solutions (Steinhoff) |
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| 17 |
Epidemiology and Control of Malaria (Morrow) |
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| 18 |
STD Epidemiology (Zenilman) |
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| 19 |
The Epidemiology of Hepatitis B and A Infections (Nelson) |
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| 20 |
Hepatitis C and E (Nelson) |
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Further Reading:
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Readings
Textbooks
Kenrad E. Nelson & Carolyn Masters Williams. Infectious Disease Epidemiology: Theory and Practice. Second Edition. Jones and Bartlett Publishers, 2006.
This text is designed to be used in the course; book chapters have been written by the course lecturers.
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| Overview of Microbiology |
Ksiazek TG, Erdman D et al. A novel coronavirus associated with severe acute respiratory syndrome. New Engl J Med 2003;348(20):1953-1966
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| The Molecular Epidemiology of Infectious Disease |
van rie A, Warren R, Richardson M, Victor TC, Gie RP, Enarson DA, Beyers N, van Helden PD. Exogenous reinfection as cause of recurrent tuberculosis after curative treatment. New Engl J Med 1999;341(15):1174-1179.
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| Modeling of Infectious Disease |
Huges JP, Garnett GP, et al. The theoretical population-level impact of a prophylactic human papilloma virus vaccine. Epidemiology 2002; 13:631-639.
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| Case-Control Studies |
Arcari C, Gaydos CA , Nieto FJ, Krauss M and Nelson KE. Association between Chlamydia pneumoniae and acute myocardial infarction in young men in the United States military: the importance of timing of exposure measurement. Clin Infect Dis 2005; 40:1123-30.
Wheeler C, Vogt TM, Armstrong GL et al. An outbreak of hepatitis A associated with green onions. N Engl J Med 2005; 353:890-7.
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| Vaccines - Impact, Questions, and Challenges |
Harper DM, Franco EL. Efficacy of a bivalent L1 virus-like particle vaccine in prevention of infectin with human papillomavirus types 16 and 18 in young women: a randomized controlled trial. Lancet 2004 (364):1757-1765.
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| Measles |
Parker AA, Staggs W, et al. Implications of a 2005 measles outbreak in Indiana for sustained elimination of measles in the United States . New Engl J Med 2006;355(5):447-455.
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| Disease Eradication |
Alexander LN , Seward JF, et al. Vaccine policy changes and epidemiology of poliomyelitis in the United States . JAMA 2004; 292:1696-1701.
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| Beyond Osler: The Past, Present, and Future of Infection Control |
Srinivasan A, Wolfenden LL, Song X, Mackie K, Hartsell TL, Jones HD, Diette GB, Orens JB, Yung RC, Ross TL, Merz W, Scheel PJ, Haponik EF, Perl TM.. An outbreak of Pseudomonas aeruginosa infections associated with flexible bronchoscopes. N Engl J Med 2003;348:91-2.
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| Interactions between Nutrition and Infection in the Developing World |
Fawzi WW, Masamanga GI, Spielman D, et al. A randomized trial of multivitamin supplements and HIV disease progression and mortality. N Engl J Med 2004; 351:23-32
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| Epidemiology of Diarrheal Diseases |
Woo PCY, Lau SKP, et al. Association of Laribacter hongkongensis in community-acquired gastroenteritis with travel and eating fish: a multicentre case control study. Lancet 2004 (363) 1941-1947.
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| TB Epidemiology |
Weis SE, Slocum Pc, Blais FX, King B, Nunn M, et al. the effect of directly observed therapy on the rates of drug resistance and relapse in tuberculosis. N Engl J Med 1994; 330:1179-1184.
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| Influenza: Virus and Disease, Epidemics and Pandemics |
Horwitz ES, Haber M, Chang A, Shope T, Teo S, Ginsberg M, Waecker N, Cox NJ. Effectiveness of influenza vaccination of day care children in reducing influenza-related morbidity among household contacts. JAMA 2000; 284:1677-1682.
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| CNS Viral Infections |
Stramer SL, Fang CT, Foster GA, Wagner AG, Brodsky JP, Dodd RY. West Nile virus among blood donors in the United States . N Engl J Med 2005; 353:451-9.
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| Lyme Disease and Its Epidemiology |
Steere AC, Sikand VK, Meurice F, Parenti DL, Fikrig EL Schoen RT, Nowakowski J, Schmid CH, Laukamp S, Buscarino C, Krause DS. Lyme Disease Vaccine Study Group. Vaccination against lyme disease with recombinant Borrelia burgdorferi outer-surface lipoprotein A with adjuvant. NEJM 1998; 339(4):209-215.
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| Meningococcal Disease: Global Problem, Local Solutions |
Imrey PB, Jackson LA, Ludwinski PH, et al. Outbreak of serogroup C meningococcal disease associated with campus bar patronage. Am J Epidemiol 1996;143:624-30.
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| Epidemiology and Control of Malaria |
Alonso PI, Sacarlal J, et al. Efficacy of the RTS,S/ASO2A vaccine against Plasmodium falciparum infection and disease in young African children : randomised controled trial. Lancet 2004 (364):1411-1420.
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| STD Epidemiology |
Wawer MJ, RH Gray et al. Rates of HIV-1 transmission per Coital Act, by state of HIV-1 infection, in Rakai , Uganda . JID 2005:191:1403-1409.
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| The Epidemiology of Hepatitis B and A Infections |
Chang M-H, Chen C-J, Lai M-S, Hsu H-M, Wu T-C, Kong M-S, Liang D-C, Shau W-Y, Chen D-S, Taiwan Childhood Hepatoma Study Group. Universal hepatitis B vaccination in Taiwan and the incidence of hepatocellular carcinoma in children. NEJM 1997; 336:1855-1859.
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| Hepatitis C and E |
El-Serag HB, Davila JA, Peterson NJ, McGlynn KA. The continuing increase in the incidence of hepatocellular carcinoma in the United States: an update. Ann Intern Med 2003;139:817-823.
El-Serag HB, Mason AC. Risk factors for the rising rates of primary liver cancer in the United States . Arch Intern med 2000; 160:3227-30.
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