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 Musculoskeletal Pathophysiology  posted by  duggu   on 11/22/2007  Add Courseware to favorites Add To Favorites  
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Abstract/Syllabus:

Robinson, Dwight R., HST.021 Musculoskeletal Pathophysiology, January IAP 2006. (Massachusetts Institute of Technology: MIT OpenCourseWare), http://ocw.mit.edu (Accessed 09 Jul, 2010). License: Creative Commons BY-NC-SA

Dramatization of Gout as a devil attacking a foot

The Gout. James Gillray, 1799. From the Philadelphia Museum of Art.

Highlights of this Course

This course features a selection of downloadable lecture notes. This course is offered during the Independent Activities Period (IAP), which is a special 4-week term at MIT that runs from the first week of January until the end of the month.

Course Description

This course covers the growth, development and structure of normal bone and joints, the biomechanics of bone connective tissues, and their response to stress, calcium and phosphate homeostasis. Additional topics include regulation by parathyroid hormone and vitamin D, the pathogenesis of metabolic bone diseases and diseases of connective tissues, joints and muscle with consideration of possible mechanisms and underlying metabolic derangements.

Syllabus

 
 

Overview

This lecture based course covers the growth, development and structure of normal bone and joints, the biomechanics of bone connective tissues, and their response to stress, calcium and phosphate homeostasis. Additional topics include regulation by parathyroid hormone and vitamin D, the pathogenesis of metabolic bone diseases and diseases of connective tissues, joints and muscle with consideration of possible mechanisms and underlying metabolic derangements.

Assignments

There is one problem set and a final exam for this course.

Grading

Activities Percentages
Problem Set 10%
Final Exam 90%
 

 

Calendar

 
 

 

 
SES # TOPICS KEY DATES
1 Bone Growth and Development (1 hr.) - Dr. Schiller

Bone Growth; Fracture Healing (1 hr.) - Dr. Schiller
 
2 Infections of Bone/Metabolic Bone Disease (1 hr.) - Dr. Schiller

Histology of Bone; Microscopic Lab (1 hr.) - Dr. Schiller
 
3 Disorders of Growth Plate (1 hr.) - Dr. Olsen

Heritable Disorders of Connective Tissues (1 hr.) - Dr. Krane
 
4 Basic Skeletal Biomechanics (1 hr.) - Dr. Snyder

Biomechanics of Fracture Healing (1 hr.) - Dr. Snyder
 
5 Cartilage Biology and Biomechanics (1 hr.) - Dr. Kim

Biomechanics in Pathogenesis of Osteoarthritis (1 hr.) - Dr. Kim
 
6 Rheumatic Diseases (I) (1 hr.) - Dr. Robinson

Rheumatic Diseases (II), SLE, Scleroderma (1 hr.) - Dr. Robinson
 
7 Pathogenesis of Rheumatoid Arthritis (1 hr.) - Dr. Anderson

Rheumatic Diseases (III), Vasculitis, Gout (1 hr.) - Dr. Robinson
 
8 Biomechanics Review Session (1 hr.)  
9 Muscular Dystrophies/ Inflammatory Myopathies (1 hr.) - Dr. Brown

Mitochondrial Myopathies (1 hr.) - Dr. Johns

Mineral Ion Homeostasis (2 hrs.) - Dr. Potts
 
10 Osteoporosis; Osteomalacia (1 hr.) - Dr. DeMay

Cartilage; Structure Osteoarthritis (1 hr.) - Dr. Mankin

Demonstration: Joint Dissection (30 min.) - Dr. Mankin
Problem set due
  Final Examination (2.5 hrs.)  
 

 




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