|
Schauer, David, and Edward DeLong, 20.106J Systems Microbiology, Fall 2006. (Massachusetts Institute of Technology: MIT OpenCourseWare), http://ocw.mit.edu (Accessed 07 Jul, 2010). License: Creative Commons BY-NC-SA
This natural rotary motor propels the flagella of E. coli cells, allowing them to move forward. (Figure by MIT OCW.)
Course Highlights
This course features complete notes as well as presentation slides in the lecture notes section.
Course Description
This course covers introductory microbiology from a systems perspective, considering microbial diversity, population dynamics, and genomics. Emphasis is placed on the delicate balance between microbes and humans, and the changes that result in the emergence of infectious diseases and antimicrobial resistance. The case study approach covers such topics as vaccines, toxins, biodefense, and infections including Legionnaire’s disease, tuberculosis, Helicobacter pylori, and plague.
Syllabus
Microbiology from a systems perspective.
Prerequisites
5.111, 5.112 or 3.091; 7.012, 7.013, or 7.014
Course Textbook
Madigan, Michael, and John Martinko. Brock Biology of Microorganisms. 11th ed. Upper Saddle River, NJ: Pearson Prentice Hall, 2006. ISBN: 0131443291.
Grading
Grading criteria.
|
ACTIVITIES
|
PERCENTAGE
|
|
Problem Sets (~1 every 2 weeks)
|
25%
|
|
Midterm I
|
20%
|
|
Midterm II
|
20%
|
|
Final Exam
|
35%
|
Calendar
Course calendar.
|
Lec #
|
TOPICS
|
LECTURERS
|
KEY DATES
|
|
1
|
Early Earth/Microbial Evolution
|
Prof. Ed DeLong
|
|
|
2
|
Cell Structure/Function
|
Prof. Ed DeLong
|
Problem set 1 out
|
|
3
|
Biological Energy Conservation
|
Prof. Ed DeLong
|
|
|
4
|
Microbial Growth
|
Prof. David Schauer
|
Problem set 1 due
|
|
5
|
Metabolic Regulation
|
Prof. Ed DeLong
|
Problem set 2 out
|
|
6
|
Virology
|
Prof. David Schauer
|
|
|
7
|
Information Flow in Biological Systems
|
Prof. Ed DeLong
|
Problem set 2 due
|
|
|
Midterm I
|
|
|
|
8
|
Regulation of Cell Activity
|
Prof. Ed DeLong
|
Problem set 3 out
|
|
9
|
Genetic Exchange in Bacteria
|
Prof. Ed DeLong
|
|
|
10
|
Experimental Evolution: Optimization of Metabolic Systems
|
Guest Lecturer, Prof. Christopher Marx from Harvard
|
Problem set 3 due
|
|
11
|
Genomics I
|
Prof. Ed DeLong
|
|
|
12
|
Genomics II
|
Prof. Ed DeLong
|
Problem set 4 out
|
|
13
|
Metabolic Diversity I
|
Prof. Ed DeLong
|
|
|
14
|
Metabolic Diversity II
|
Prof. Ed DeLong
|
|
|
15
|
Microbial Ecology
|
Prof. Ed DeLong
|
Problem set 4 due
|
|
|
Midterm II
|
|
|
|
16
|
Microbial Growth Control
|
Prof. David Schauer
|
Problem set 5 out
|
|
17
|
Microbe-host Interactions
|
Prof. David Schauer
|
|
|
18
|
Immunology I
|
Megan McBee
|
|
|
19
|
Immunology II
|
Megan McBee
|
Problem set 5 due
|
|
20
|
Diagnostic Microbiology
|
Prof. David Schauer
|
Problem set 6 out
|
|
21
|
Person-to-person Transmission
|
Prof. David Schauer
|
|
|
22
|
Epidemiology
|
Megan McBee
|
Problem set 6 due
|
|
23
|
Animal- and Arthropod-transmitted Diseases
|
Prof. David Schauer
|
|
|
24
|
Review
|
Prof. David Schauer
|
|
|
|
Final Exam
|
|
|